Molecular BiologybioRxivPreprint
Cryo-EM reveals how ASX-173 inhibits human asparagine synthetase to activate the integrated stress response
Kirk A. Staschke, Nicholas T. Walda, Lucciano A. Pearce…·Yuichiro Takagi
The paper describes how ASX-173 inhibits asparagine synthetase, induces the integrated stress response, and reduces cell growth in HEK-293A cells.
DOI 10.1101/2025.10.16.682859