Author

Lucciano A. Pearce

Florida State UniversityORCID 0009-0009-1446-8169Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:microscopy & imaging analysis· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Wen ZhuiD· 2 shared Yuichiro TakagiiD· 2 shared Adriana CoricelloiD· 1 shared Alanya J. Nardone· 1 shared Giovanni BottegoniiD· 1 shared Kirk A. StaschkeiD· 1 shared Nicholas T. WaldaiD· 1 shared Ronald C. WekiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

Wen ZhuORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintFeb 3, 2026

Conformational Remodeling Underlies Activity Loss in Disease-Linked Asparagine Synthetase Variant

Lucciano A. Pearce, Adriana Coricello, Alanya J. Nardone…·Wen Zhu

This study investigates how a specific mutation in the ASNS gene impairs enzyme function by disrupting conformational dynamics, using biochemical, cryo-EM, and molecular dynamics approaches.

DOI 10.64898/2026.02.01.703106

humanstructural biology

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Molecular BiologybioRxivPreprintOct 16, 2025

Cryo-EM reveals how ASX-173 inhibits human asparagine synthetase to activate the integrated stress response

Kirk A. Staschke, Nicholas T. Walda, Lucciano A. Pearce…·Yuichiro Takagi

The paper describes how ASX-173 inhibits asparagine synthetase, induces the integrated stress response, and reduces cell growth in HEK-293A cells.

DOI 10.1101/2025.10.16.682859

humanexperimental assay

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