Aarav Mehta

The paper provides an open resource for automated ecDNA quantification, comparing methods and introducing ecCount to reduce count bias.

The paper shows that ecDNA allows tumors to adapt rapidly by maintaining a spectrum of gene expression levels across cells, rather than relying on clonal expansion.

This study introduces an automated pipeline for detecting and quantifying ecDNA in FISH images to analyze drug response mechanisms in cancer cells.

CytoCellDB is a database that expands the number of cancer cell lines with ecDNA annotations, enabling analysis of ecDNA in relation to molecular data and drug responses.