Angeline Wu

This study examines how human enteroids respond to various injuries, finding limited reactivation of developmental gene programs and highlighting the role of specific signaling pathways.

The paper constructs a developmental cell atlas of the human esophagus and develops in vitro models that recapitulate esophageal architecture, revealing WNT2B's role in regulating basal progenitor self-renewal.

The paper constructs a cellular atlas of the early postnatal human lung and identifies two distinct AT2 cell states linked to inflammatory signaling and clinical interventions.

This paper develops a long-term in vitro model of human colonic epithelium that maintains barrier function for up to 30 days and responds to various challenges.

The paper maps mesenchymal diversity in the developing human intestine and organoids using single-cell RNA-sequencing and spatial transcriptomics, identifying distinct fibroblast populations and their spatial organization.

The paper creates a spatially-resolved atlas of the developing human lung, identifying a WNT-driven niche that regulates basal cells.

The paper identifies a novel APOE+ elastin-producing valve interstitial cell subtype and reveals the APOE-NOTCH signaling axis regulates elastogenesis during human cardiac valve remodeling.

The paper identifies a novel secretory-like cell type in the developing human lung that gives rise to pulmonary neuroendocrine cells and multiciliated cells.

The paper identifies EPIREGULIN as a niche factor that enables spatial organization in human intestinal organoids, mimicking the native intestine's structure and gene expression.

The paper identifies R-SPONDIN2-expressing mesenchymal cells as a niche for lung bud tip progenitors using single-cell RNA sequencing and functional experiments.

This study uses scRNA-seq to analyze human intestinal development, identifying cell sources of niche factors and their functional roles in stem cell maintenance.

This study enhances the co-differentiation of intestinal organoids with endothelial cells, showing they share an intestinal-specific transcriptional signature with native cells.

The paper uses human intestinal organoids to create a single-cell transcriptome atlas, revealing molecular mechanisms of cell fate specification in the intestine.

The paper identifies SMAD signaling as a regulator of basal cell fate specification in the developing human lung using single-cell transcriptomics and organoid models.

This study shows that non-adhesive alginate hydrogels support the growth and differentiation of human intestinal organoids, comparable to Matrigel.