Peter J. I. Ellis

Myosin VI orchestrates estrogen-driven gene expression in breast cancer cells.

This study shows Myosin VI regulates estrogen receptor activity and gene expression in breast cancer, with MVI inhibition enhancing hormone therapy effectiveness.

Explaining the counter-intuitive effectiveness of trophectoderm biopsy for PGT-A using computational modelling

The paper uses computational modeling to show that while biopsy results are poor predictors of individual embryo mosaicism, they can still be used to rank embryos for transfer in PGT-A.

Generating single-sex litters: development of CRISPR-Cas9 genetic tools to produce all-male offspring

The paper develops CRISPR-Cas9 tools to generate all-male mouse litters by targeting the Topoisomerase 1 gene with a bicomponent system.

Differential sperm motility mediates the sex ratio drive shaping mouse sex chromosome evolution

The paper shows that X-bearing sperm have greater motility than Y-bearing sperm in mice with Yq deletions, leading to a skewed sex ratio.

A conserved requirement for Fbxo7 during male germ cell cytoplasmic remodelling

This paper shows that Fbxo7 is required for male fertility in mice, as its deficiency leads to sterile males with abnormal spermatid disposal during spermiogenesis.

Quasi-Mendelian Paternal Inheritance of mitochondrial DNA: A notorious artifact, or anticipated mtDNA behavior?

The paper challenges previous interpretations of biparental mtDNA inheritance, proposing a model where paternal mtDNA undergoes selective fixation due to initial low copy number and a selective advantage.

A high-throughput method for unbiased quantitation and categorisation of nuclear morphology

The paper develops a program to quantify and categorize nuclear morphology in mouse sperm, finding increased shape variability in lab lines compared to wild-derived lines and subtle cross-direction effects in F1 offspring.

Automated nuclear cartography reveals conserved sperm chromosome territory localization across 2 million years of mouse evolution

The paper develops an automated method to map FISH signals in sperm nuclei and finds conserved chromosome territory organization across mouse lineages.