Fatemah Mukadum

This study uses cryo-EM and myosin motors to show that wild-type α-actinin-4 forms two binding states with F-actin, while the K255E variant only forms strong bonds, revealing a force-induced transition mechanism for catch bonding.

This study uses molecular dynamics simulations to assess vinculin-actin unbinding kinetics, revealing catch bonding behavior under force and showing how directional forces influence bond states.