Author

Alfred C. Chin

Rockefeller UniversityORCID 0000-0001-6383-2689Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Fatemah MukadumiD· 1 shared Glen M. HockyiD· 1 shared Gregory M. AlushiniD· 1 shared Matthew J. ReynoldsiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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4 top collaborators · 6 mutual co-author links

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1 shared paperBiophysics

Fatemah MukadumORCID

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1 paper

Recent·Most cited

BiophysicsbioRxivPreprintApr 12, 2026

Force-modulated structural landscape of the catch bonding F-actin crosslinker α-actinin-4

Alfred C. Chin, Fatemah Mukadum, Matthew J. Reynolds…·Gregory M. Alushin

This study uses cryo-EM and myosin motors to show that wild-type α-actinin-4 forms two binding states with F-actin, while the K255E variant only forms strong bonds, revealing a force-induced transition mechanism for catch bonding.

DOI 10.64898/2026.03.04.709699

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