Author

Matthew J. Reynolds

Rockefeller UniversityORCID 0000-0002-2501-9280Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:cryo-EM· 4 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Gregory M. AlushiniD· 3 shared Xiaoyu SuniD· 2 shared Alex J. NobleiD· 1 shared Alfred C. ChiniD· 1 shared Ayala G. Carl· 1 shared Brian T. ChaitiD· 1 shared Donovan Y.Z. PhuaiD· 1 shared Fatemah MukadumiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiophysics

Gregory M. AlushinORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Myosin forces elicit an F-actin structural landscape that mediates mechanosensitive protein recognition

Ayala G. Carl, Matthew J. Reynolds, Xiaoyu Sun, Pinar S. Gurel, Donovan Y.Z. Phua, Keith Hamilton, Lin Mei, John W. Watters, Yasuharu Takagi, Alex J. Noble, James R. Sellers, Gregory M. Alushin

The paper shows myosin forces alter F-actin structure, creating a landscape that -catenin recognizes, revealing a mechanism for mechanosensitive signaling.

Nature · Apr 22, 2026Peer-reviewedBiophysics

Force-modulated structural landscape of the catch bonding F-actin crosslinker α-actinin-4

Alfred C. Chin, Fatemah Mukadum, Matthew J. Reynolds, Glen M. Hocky, Gregory M. Alushin

This study uses cryo-EM and myosin motors to show that wild-type α-actinin-4 forms two binding states with F-actin, while the K255E variant only forms strong bonds, revealing a force-induced transition mechanism for catch bonding.

bioRxiv · Apr 12, 2026 · PreprintBiophysics

Afadin mediates cadherin-catenin complex clustering on F-actin linked to cooperative binding and filament curvature

Rui Gong, Matthew J. Reynolds, Xiaoyu Sun, Gregory M. Alushin

This study shows afadin and vinculin enhance cadherin-catenin complex binding to F-actin, stabilizing it through cooperative interactions and promoting filament curvature.

Science Advances · Feb 14, 2025Peer-reviewedBiophysics

Distinct modes of coupling between VCP, an essential unfoldase, and deubiquitinases

Lauren E. Vostal, Noa E. Dahan, Wenzhu Zhang, Matthew J. Reynolds, Brian T. Chait, Tarun M. Kapoor

This study identifies how VCP interacts with DUBs at distinct sites to coordinate ubiquitin removal during protein recycling.

The Journal of Cell Biology · Feb 10, 2025Peer-reviewedBiochemistry