Dejiang Wang

This study introduces fungal-DBiT, a spatial transcriptomic platform that maps host and fungal RNAs in tissue sections, revealing spatial heterogeneity in fungal localization and host responses during infection and under physiological conditions.

The paper identifies immune-enriched fibrovascular cores in papillary tumors that create immunosuppressive niches through PAI-1-driven macrophage fusion.

This study identifies ECM-dominant cardiovascular diseases as driven by coordinated CDKN1A and CDKN2A senescence programs in fibroblasts and shows senolytic treatments improve cardiac function.

This study uses single-nucleus and spatial ATAC-seq to uncover epigenomic heterogeneity and spatial niches in non-functional pancreatic neuroendocrine tumors.

Spatial tri-omic sequencing (DBiT ARP-seq and DBiT CTRP-seq) and CODEX imaging map chromatin, RNA, and protein dynamics across mammalian brain development and lysolecithin-induced neuroinflammation.