Author

Lü Long

Massachusetts Institute of TechnologyORCID 0009-0003-8923-5518Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:database / resource· 1 Assay:DNA methylation· 1 Organism:E. coli· 1 Assay:Hi-C· 1

Frequent Co-Authors

Alicia D. D’SouzaiD· 1 shared Ann C. Mladek Tuma· 1 shared Annie Zhu· 1 shared Bin ZhangiD· 1 shared Brett L. CarlsoniD· 1 shared Cameron T. FloweriD· 1 shared Charles A. WhittakeriD· 1 shared Daniel Flam-ShepherdiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperSystems Biology

Alicia D. D’SouzaORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BiophysicsNature GeneticsPeer-reviewedSep 25, 2026

Euchromatin forms condensed domains with short active regions on the surface

Joseph M. Paggi, Lü Long, Bin Zhang

The paper develops a simulation framework to infer nucleosome-resolution chromatin structures from RCMC data, revealing euchromatin as condensed domains with accessible promoter/enhancer regions.

9 citationstop 1%

Hi-Csimulation

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Molecular BiologybioRxivPreprintSep 11, 2026

✦ In-depth digest

RNA-guided transcriptional repression by TIGR-Tas systems

Peiyu Xu, Lü Long, Annie Zhu…·Feng Zhang

TIGRFinder annotated 6,685 TIGR arrays; cryo-EM structures show inactive RuvC domains, and E. coli reporter assays show CsTasR and MbTasA repress transcription in a guide-dependent manner.

DOI 10.64898/2026.09.09.750476

virusbacteria (other)

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Systems BiologyNature CommunicationsPeer-reviewedAug 8, 2026

Uncovering the signaling networks of disseminated glioblastoma cells in vivo with INSIGHT

Ryuhjin Ahn, Alicia D. D’Souza, Lawrence Long…·Forest M. White

The paper introduces INSIGHT, a platform for phosphoproteomic analysis of rare cell subpopulations, and applies it to study signaling changes in disseminated glioblastoma cells in vivo.

1 citation

mouseproteomics

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