Peiyu Xu

TIGRFinder annotated 6,685 TIGR arrays; cryo-EM structures show inactive RuvC domains, and E. coli reporter assays show CsTasR and MbTasA repress transcription in a guide-dependent manner.

The paper reports the structures of TSHR activated by TSH and an autoantibody, revealing a universal activation mechanism and the role of cholesterol in TSHR localization.

The paper reports the structures of galanin bound to its receptors and G proteins, revealing the molecular basis for allosteric agonism and G protein subtype selectivity.

The paper reports cryo-EM structures of LHCGR in different activation states, revealing a push and pull mechanism of receptor activation and the role of an allosteric agonist.

This study determines cryo-EM structures of dual and triple agonists bound to GIPR, GLP-1R, and GCGR to elucidate their superior efficacy over monoagonists in glucose homeostasis.

The paper reports cryo-EM structures of GLP-1R with ago-allosteric modulators, revealing their mechanism of action and providing insights for therapeutic design.