Cell BiologybioRxivPreprint
From anti-fungal to potential neurotherapeutic: Posaconazole as an effective inhibitor of cellular TDP-43 pathology
Noah Nathan Kochen, Sophia Zafari, Aimee Renaud…·Jonathan N. Sachs
This study identifies posaconazole as a more effective and safer alternative to ketoconazole for inhibiting TDP-43 pathology in ALS/FTD by reducing aggregation and restoring SREBP2 levels.
DOI 10.64898/2026.06.01.728552