Noah Nathan Kochen

From anti-fungal to potential neurotherapeutic: Posaconazole as an effective inhibitor of cellular TDP-43 pathology

This study identifies posaconazole as a more effective and safer alternative to ketoconazole for inhibiting TDP-43 pathology in ALS/FTD by reducing aggregation and restoring SREBP2 levels.

Fluorescence lifetime-based FRET biosensors for monitoring N-terminal domain interactions of TDP-43 in living cells: A novel resource for ALS and FTD drug discovery

The paper develops FRET biosensors to monitor TDP-43 N-terminal domain interactions and identifies ketoconazole as a potential drug candidate for ALS and FTD.