Giulia Micoli

This study maps the spatio-temporal DNA methylation patterns in ovarian cancer using longitudinal data from the DECIDER trial, showing early establishment of regulatory methylomes and their stability through treatment.

The paper identifies reduced IFN-I pathway activity as a driver of chemo-refractory ovarian cancer using multi-omics analysis in a clinical trial cohort.

SegmentQTL improves molQTL analysis in copy number-driven cancers by incorporating breakpoint information to reduce false discoveries and refine associations.

This study shows chemotherapy causes myeloid-driven spatial T-cell exhaustion in ovarian cancer by altering immune cell states and interactions, suggesting new immunotherapy approaches.

GenomeSpy is a grammar-based visualization toolkit for genomic data analysis that enables interactive exploration of large datasets, demonstrated on ovarian cancer samples.