Daria Afenteva

Spatio-Temporal Landscape of Whole-Genome DNA Methylation Patterns in Ovarian Cancer

This study maps the spatio-temporal DNA methylation patterns in ovarian cancer using longitudinal data from the DECIDER trial, showing early establishment of regulatory methylomes and their stability through treatment.

Identification of Monotonically Classifying Pairs of Genes for Ordinal Disease Outcomes

This study extends a gene pair classification method to ordinal outcomes, showing comparable performance with higher interpretability in glioblastoma and ovarian cancer.

Multi-Omics Analysis Reveals the Attenuation of the Interferon Pathway as a Driver of Chemo-Refractory Ovarian Cancer

The paper identifies reduced IFN-I pathway activity as a driver of chemo-refractory ovarian cancer using multi-omics analysis in a clinical trial cohort.

Multi-Omics Characterization of ctDNA Release Mechanisms in Ovarian Cancer

This study identifies molecular drivers of ctDNA variability in ovarian cancer by analyzing genomic and transcriptomic data from 118 patients, linking ctDNA levels to proliferation and immune activity.

SegmentQTL: Identifying genetic variants influencing molecular phenotypes in copy number-driven cancers

SegmentQTL improves molQTL analysis in copy number-driven cancers by incorporating breakpoint information to reduce false discoveries and refine associations.

Chemotherapy induces myeloid-driven spatial T-cell exhaustion in ovarian cancer

This study shows chemotherapy causes myeloid-driven spatial T-cell exhaustion in ovarian cancer by altering immune cell states and interactions, suggesting new immunotherapy approaches.