Single-cell spatial atlas of high-grade serous ovarian cancer unveils MHC class II as a key driver of spatial tumor ecosystems and clinical outcomes
Fernando Pérez‐Villatoro, Aleksandra Shabanova, Lilian van Wagensveld, Ada Junquera, Iga Niemiec, María Mercedes Hincapié-Otero, Ziqi Kang, Matías Marín Falco, Kürşat Birgin, Sarah Wolf, Ella Anttila, Gayani Anandagoda, Julia Casado, Eric Marcus, Duco Gaillard, , Anniina Färkkilä
Cyclic immunofluorescence of 265 high-grade serous ovarian carcinomas and random-forest feature ranking identify cancer-cell MHC-II as an adjusted predictor of longer survival marking immune-activated tumor-stroma hotspots.
Cancer Discovery · Feb 9, 2026Peer-reviewedCancer Biology✦ In-depth digest