LPS binding caspase activation and recruitment domains (CARDs) are bipartite lipid binding modules
Anh Cao, Pascal Devant, Chengliang Wang, Mengyu Sun, Stephanie N. Kennedy, Weiyi Ma, Jianbin Ruan, Jonathan C. Kagan
This study identifies the caspase-11 CARD as a bipartite lipid-binding module that recognizes both self and nonself lipids, enabling the design of an LPS-binding domain.
Science Advances · Mar 7, 2025Peer-reviewedImmunology