Author

Jianbin Ruan

UConn HealthORCID 0000-0001-5843-8273Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Andrew G. HarrisoniD· 1 shared Anh CaoiD· 1 shared Anthony T. VellaiD· 1 shared Chengliang WangiD· 1 shared Chengliang WangiD· 1 shared Duomeng YangiD· 1 shared Evelyn TeraniD· 1 shared Jason G. Cahoon· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Andrew G. HarrisonORCID

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2 papers

Recent·Most cited

ImmunologyScience AdvancesPeer-reviewedMar 7, 2025

LPS binding caspase activation and recruitment domains (CARDs) are bipartite lipid binding modules

Anh Cao, Pascal Devant, Chengliang Wang…·Jonathan C. Kagan

This study identifies the caspase-11 CARD as a bipartite lipid-binding module that recognizes both self and nonself lipids, enabling the design of an LPS-binding domain.

11 citations

mousezebrafish

𝕏 PostBluesky

ImmunologybioRxivPreprintOct 30, 2024

Unanchored ubiquitin chains promote the non-canonical inflammasome via UBXN1

Duomeng Yang, Jason G. Cahoon, Tingting Geng…·Jianbin Ruan

This study identifies UBXN1's role in activating the non-canonical inflammasome via unanchored ubiquitin chains, showing its importance in sepsis and inflammasome signaling.

DOI 10.1101/2024.10.30.621131

mouseproteomics

𝕏 PostBluesky