Pascal Devant

This study identifies HDAC5 as a regulator of effector competence in human CD8+ T cells, showing it modulates cytokine responses and TCR activation through an ACTL6A-IRF4 axis.

This paper develops a virus-like particle-based system for CRISPR gene editing and screening in primary human myeloid cells, identifying TNFAIP3 as a key regulator of inflammatory polarization.

This study identifies NLRP11 as a primate-specific factor that enhances CASP4-mediated cLPS detection and non-canonical inflammasome activation in human macrophages.

This study identifies NINJ1 as a mediator of plasma membrane rupture in Mtb-infected macrophages, showing it operates independently of canonical cell death pathways and requires the ESX-1 secretion system.

This study identifies the caspase-11 CARD as a bipartite lipid-binding module that recognizes both self and nonself lipids, enabling the design of an LPS-binding domain.