Microbiome-Derived Prion-Like Proteins and Their Potential to Trigger Cognitive Dysfunction
Jofre Seira Curto, Adan Dominguez Martinez, Paula Sotillo Sotillo, Martina Serrat Garcia, Monica Girona del Pozo, M. Rosario Fernández, Natalia Sánchez de Groot
The paper shows that 63% of gut microbiome proteins have prion-like sequences that can form amyloid fibrils, impair memory in C. elegans, and may contribute to neurodegenerative diseases.
bioRxiv · Oct 19, 2023 · PreprintMolecular Biology