Author

Zixi Yun

Case Comprehensive Cancer CenterORCID 0009-0004-0610-8351Unclaimed ORCID profile · follow to get notified of new preprints

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Zixi Yun1 paper · Case Western Reserve University

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Chen WuiD· 1 shared Chun-Peng Pai· 1 shared Donald Patrick McDonnelliD· 1 shared Han Wang· 1 shared Hung‐Ying KaoiD· 1 shared Jiangan Yue· 1 shared Kristen L. Weber-BonkiD· 1 shared Lisheng GengiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Chen WuORCID

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1 paper

Recent·Most cited

Cancer BiologyMolecular Cancer TherapeuticsPeer-reviewedSep 10, 2025

Mitoxantrone inhibits and downregulates ERα through binding at the DBD-LBD interface

Han Wang, Yuxuan Luo, Sandeep Artham…·Sichun Yang

This study shows mitoxantrone inhibits ERα by binding at the DBD-LBD interface, causing conformational changes and degradation, and effectively targets ER mutations resistant to current therapies.

DOI 10.1158/1535-7163.mct-25-0405

humanproteomics

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