Sandeep Artham

Dietary methionine restriction primes T cell metabolism for activation and tumor inhibition and enhances the efficacy of immune checkpoint blockade

This study shows that dietary methionine restriction enhances T cell metabolism and improves anti-PD1 checkpoint blockade efficacy in immunocompetent tumor models.

Mitoxantrone inhibits and downregulates ERα through binding at the DBD-LBD interface

This study shows mitoxantrone inhibits ERα by binding at the DBD-LBD interface, causing conformational changes and degradation, and effectively targets ER mutations resistant to current therapies.

Estrogens increase cancer cell efferocytosis to establish an immunosuppressive tumor microenvironment

This study shows that estrogens enhance tumor-associated macrophage efferocytosis, promoting immunosuppression, and demonstrates that targeting the E2/ER/CX3CR1 axis can reverse this effect and improve radiation therapy.

UDP-6-glucose dehydrogenase in hormonally responsive breast cancers

This study shows that UGDH knockdown reduces estrogen-induced tumorigenic traits in breast cancer models and validates findings in human clinical specimens.