Sichun Yang

The paper introduces MARS, a simulation framework that resolves conformational heterogeneity in IDPs by integrating experimental data from SAXS and PRE, revealing two major states in ER-NTD.

This study shows mitoxantrone inhibits ERα by binding at the DBD-LBD interface, causing conformational changes and degradation, and effectively targets ER mutations resistant to current therapies.

This paper identifies PML1 as a driver of endocrine resistance in ER+ breast cancer by forming a feedforward loop with PI3K and MAPK pathways, and shows that arsenic trioxide can disrupt this loop.