Lora K. Heisler

This paper provides a detailed protocol for stereotaxic targeting of the Dorsal Vagal Complex in mice, including surgical access, coordinate system, injection parameters, and histological validation.

This study evaluates AAV-mediated delivery of leptin and adiponectin in a mouse model of congenital generalized lipodystrophy, finding that leptin improves metabolic health while adiponectin does not.

The paper identifies a brain serotonin circuit that contributes to age-related decline in physical activity and shows it can be reversed by targeting specific receptors.

This study shows that NRM serotonergic neurons bidirectionally control spinal nociception through different 5-HT receptors, with 5-HT2c mediating analgesia and 5-HT3 causing hyperalgesia.

The paper identifies GABAergic neurons in the nucleus of the solitary tract (NTS) as a new modulator of feeding behavior and body weight by suppressing orexigenic AgRP/NPY neurons through projections to the hypothalamic arcuate nucleus.

This study identifies brainstem GLP-1 neurons as essential for lorcaserin's effect on reducing food intake in mice and suggests combination therapy with GLP-1R agonists may enhance efficacy.