Author

Isabella Ferrara

Merck KGaA, Darmstadt (Germany)ORCID 0009-0004-1145-4232Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Aaron S. PetruzzellaiD· 1 shared Adrian W. DobbelsteiniD· 1 shared Ana R. Lemos· 1 shared Arne SchneuingiD· 1 shared Artem Y. LyubimoviD· 1 shared Bruno E. CorreiaiD· 1 shared David Robin Pavel Iosub· 1 shared Davide M. FerrarisiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBioinformatics

Aaron S. PetruzzellaORCID

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2 papers

Recent·Most cited

A Unified 3D Generative Model for Synthesizable Structure-Based Drug Design

Ilia Igashov, Arne Schneuing, Adrian W. Dobbelstein, Irina Morozova, Rebecca M. Neeser, Kara Zielinski, Luciano A. Abriata, Aaron S. Petruzzella, David Robin Pavel Iosub, Olivia Gampp, Artem Y. Lyubimov, Evgenia Elizarova, Isabella Ferrara, Pedro M. F. Sousa, Ana R. Lemos, , Bruno E. Correia

This paper introduces LDDM, a generative model for drug design that produces synthetically accessible compounds validated experimentally for five protein targets.

bioRxiv · Sep 18, 2026 · PreprintBioinformatics

Evaluation of Thiol-Mediated Uptake in VHL-Based PROTACs

Isabella Ferrara, Karl Gademann

This study evaluates the cytotoxic effects of VHL-based PROTACs modified with 1,2-dithiolane handles, finding increased or equivalent cytotoxicity in cancer cells compared to unmodified compounds.

bioRxiv · Dec 5, 2025 · PreprintBiochemistry