Karl Gademann

This study determines the structure of the antifungal compound AFC and revises its biosynthetic pathway, showing it is derived from cis-vaccenic acid via ω-modification rather than citric acid conjugation.

This study evaluates the cytotoxic effects of VHL-based PROTACs modified with 1,2-dithiolane handles, finding increased or equivalent cytotoxicity in cancer cells compared to unmodified compounds.

The paper investigates a gene cluster that produces both enantiomerically pure and racemic metabolites through a stereodivergent pathway involving a dihydrosydnone N-oxide intermediate.

This study designs and synthesizes leudiazen analogs that inhibit Pseudomonas syringae virulence without killing the bacteria, reducing resistance risk.

The paper develops a cell surface display system in Chlamydomonas reinhardtii by identifying functional anchoring points for protein expression on the cytoplasmic membrane and cell wall.

This paper develops biohybrid microswimmers loaded with antibiotics to treat bacterial infections with precise spatial and temporal drug delivery.