SIRT5-dependent regulation of ASL controls arginine metabolism and T cell function
Kim Han, Rachael J. Klein, Kaiyuan Wu, Anna Chiara Russo, Allison M. Meadows, Thomas C Recupero, Rahul Sharma, Anand Kumar Gupta, Nathan T. Brandes, Benjamin H. Schwarz, Michael N. Sack
This study identifies SIRT5 as a key regulator of arginine metabolism and T cell function through its interaction with ASL, showing that SIRT5 depletion reduces anti-inflammatory effects of NAD+ precursors.
bioRxiv · Jun 29, 2026 · PreprintImmunology