Kim Han

This study identifies SIRT5 as a key regulator of arginine metabolism and T cell function through its interaction with ASL, showing that SIRT5 depletion reduces anti-inflammatory effects of NAD+ precursors.

This study shows BLOC1S1 deficiency in CD4+ T cells leads to altered lysosomal and exosomal dynamics, enhancing Th2 immune responses through exosome-mediated cytokine export.

This paper identifies a biphasic regulatory loop where type 1 interferon initially enhances mitochondrial fatty acid oxidation (FAO) to amplify its own production, but excessive IFN signaling induces ISG15-mediated inhibition of FAO, creating a negative feedback loop to control inflammation.

This study shows that BLOC1S1 depletion disrupts mitochondrial integrity, leading to TH2 cell immunity and allergy susceptibility via STING-NF-κB signaling.

The paper identifies autophagic and mitochondrial dysfunctions in SARS-CoV-2 infection through transcriptome profiling and network analysis of cell lines and human samples.