Author

Rachael J. Klein

National Institutes of HealthORCID 0000-0002-4289-0887Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

Anand Kumar GuptaiD· 2 shared Kim HaniD· 2 shared Michael N. SackiD· 2 shared Rahul Sharma· 2 shared Allison M. MeadowsiD· 1 shared Anna Chiara RussoiD· 1 shared Benjamin H. SchwarziD· 1 shared Christian A. CombsiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersImmunology

Anand Kumar GuptaORCID

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2 papers

Recent·Most cited

SIRT5-dependent regulation of ASL controls arginine metabolism and T cell function

Kim Han, Rachael J. Klein, Kaiyuan Wu, Anna Chiara Russo, Allison M. Meadows, Thomas C Recupero, Rahul Sharma, Anand Kumar Gupta, Nathan T. Brandes, Benjamin H. Schwarz, Michael N. Sack

This study identifies SIRT5 as a key regulator of arginine metabolism and T cell function through its interaction with ASL, showing that SIRT5 depletion reduces anti-inflammatory effects of NAD+ precursors.

bioRxiv · Jun 29, 2026 · PreprintImmunology

ISG15 orchestrates dynamic crosstalk between mitochondrial fat oxidation and type 1 interferon in myeloid cells

Anand Kumar Gupta, Jing Wu, Pijush K. Das, Rahul Sharma, Sonali Das, Kim Han, Rachael J. Klein, Rebecca D. Huffstutler, Christian A. Combs, Warren J. Leonard, Claudia Kemper, Erin E. West, Michael N. Sack

This paper identifies a biphasic regulatory loop where type 1 interferon initially enhances mitochondrial fatty acid oxidation (FAO) to amplify its own production, but excessive IFN signaling induces ISG15-mediated inhibition of FAO, creating a negative feedback loop to control inflammation.

bioRxiv · Jan 21, 2026 · PreprintImmunology