Kaiyuan Wu

This study identifies SIRT5 as a key regulator of arginine metabolism and T cell function through its interaction with ASL, showing that SIRT5 depletion reduces anti-inflammatory effects of NAD+ precursors.

This study shows BLOC1S1 deficiency in CD4+ T cells leads to altered lysosomal and exosomal dynamics, enhancing Th2 immune responses through exosome-mediated cytokine export.

This study shows that BLOC1S1 depletion disrupts mitochondrial integrity, leading to TH2 cell immunity and allergy susceptibility via STING-NF-κB signaling.