Life-long hydroxyurea treatment decreases chronic sickle cell disease pain
Nya Gayluak, Sourav Roy, Ashley N. Plumb, Hemanth Mydugolam, Zulmary Manjarres, Lindsey E Ramos Freitas, Amanda M. Brandow, Michael D. Burton, Katelyn E. Sadler
This study shows that lifelong hydroxyurea treatment reduces chronic pain in sickle cell disease mice by decreasing immune activity and reversing TRPA1 sensitization.
bioRxiv · Aug 30, 2025 · PreprintPhysiology