Hemanth Mydugolam

The paper maps molecular features of human spinal cord dorsal and ventral horns, identifying neuronal types and sex-specific glial differences using single-nucleus sequencing and spatial transcriptomics.

This study identifies transcriptomic signatures in GBS patients that reveal leukocyte interactions with peripheral nerves and pain pathways, suggesting therapeutic targets for neuropathic pain.

This study shows that lifelong hydroxyurea treatment reduces chronic pain in sickle cell disease mice by decreasing immune activity and reversing TRPA1 sensitization.

This study shows that type I interferons increase excitability of human dorsal root ganglion nociceptors and sensitize TRPV1, contributing to pain.