Jens Puschhof

This study shows that WNT signaling enables immune evasion in BRAF-mutant colorectal cancer, promoting tumor progression through changes in T cell phenotypes.

This study shows that a Western-style diet reprograms c-Kit⁺ secretory cells into tumor-initiating cells via microbial shifts and inflammation.

This study establishes venom gland organoids from Colubridae snakes and shows in vitro toxin production.

This study shows lithium affects behavior and physiology through the gut-brain axis by activating gut enterochromaffin cells, challenging the belief that lithium acts directly on the brain.

This study compares hiPSC-derived intestinal epithelial cells cultured in organoids, Transwells, and intestine-on-chip systems, showing that the latter promotes stronger gene expression related to nutrient and drug metabolism and a more mature state.

The paper uses CRISPR/Cas9 to generate mutant intestinal organoids and identifies TMPRSS2 as a critical host factor for multiple coronaviruses.