BiochemistryChemBioChemPeer-reviewed
Development of a genetically encoded and potent PDE6D inhibitor
Atanasio Gómez‐Mulas, Elisabeth Schaffner‐Reckinger, Hanne Peeters…·Daniel Abankwa
This study develops a genetically encoded PDE6D inhibitor, SNAP-STI, which shows higher potency than small molecule inhibitors but does not effectively inhibit K-Ras membrane anchorage or MAPK signaling.