Atanasio Gómez‐Mulas

K-Ras controls asymmetric cell divisions from the primary cilium

This study shows K-Ras4B sustains ciliation during muscle cell differentiation by localizing to the primary cilium, affecting asymmetric cell divisions and differentiation outcomes.

Regulation of de- and reciliation by KRAS during muscle cell differentiation

This study investigates how KRAS regulates de- and re-ciliation in muscle stem- and progenitor cells through interactions with CEP55, Aurora kinase A, and the PDE6D trafficking pathway.

Development of a genetically encoded and potent PDE6D inhibitor

This study develops a genetically encoded PDE6D inhibitor, SNAP-STI, which shows higher potency than small molecule inhibitors but does not effectively inhibit K-Ras membrane anchorage or MAPK signaling.

Nanobodies as therapies for loss-of-function misfolding diseases.

This study develops and characterizes six nanobodies as potential therapeutics for PH1 by targeting misfolded AGT variants, showing high affinity and functional enhancement in cellular models.

The lack of trade-off between conformational stability and binding affinity in a nanobody with therapeutic potential for a misfolding disease

This study shows that reducing the stability of a nanobody does not affect its binding affinity, suggesting stability and affinity can be decoupled in therapeutic proteins.

Thermodynamic versus kinetic basis for the high conformational stability of nanobodies for therapeutic applications

This study shows that nanobodies' thermal stability is primarily thermodynamic, using a two-state denaturation model across a wide temperature range.