Matthew James Smith

The paper shows OSGIN1 and OSGIN2 antagonize each other to regulate RhoA activity and ensure cytokinesis completion.

This paper introduces SPaRTa, an inducible system to study GTPase-effector interactions, showing that KRAS activation leads to distinct effector recruitment and signaling dynamics.

This study develops a genetically encoded PDE6D inhibitor, SNAP-STI, which shows higher potency than small molecule inhibitors but does not effectively inhibit K-Ras membrane anchorage or MAPK signaling.

This study identifies STRIPAK's role in promoting cytoneme biogenesis through Slik's membrane-sculpting function, which drives cell proliferation in Drosophila.

The paper maps the interactome of ARF and ARL proteins using BioID, identifies new localizations, and reveals functional roles of ARL14 in activating PLD1 and cargo trafficking.