NeurosciencebioRxivPreprint
Human induced pluripotent stem cell-derived microglia contribute to thepathophysiology of Fragile X syndrome via increased RAC1 signaling
Poulomi Banerjee, Shreya Das Sharma, Karen Burr…·Siddharthan Chandran
This study shows that FMRP loss in microglia increases RAC1 signaling, leading to inflammation and neuronal hyperexcitability in FXS, which can be mitigated by RAC1 inhibition.
DOI 10.1101/2024.06.24.600387