Engineering synthetic agonists for targeted activation of Notch signaling
David H. Perez, Daniel Antfolk, Shiun Chang, Xiomar Bustos, Elliot Medina, Ahmed Ramadan, David González-Pérez, Daniel Abate‐Daga, Paulo C. Rodrı́guez, Vincent C. Luca
This paper develops synthetic Notch agonists (SNAGs) that activate Notch signaling by pulling on mechanosensitive receptors, demonstrating their effectiveness in targeting multiple biomarkers.
Nature Chemical Biology · Sep 24, 2025Peer-reviewedSynthetic Biology