Author

Melissa Elgie

University of TorontoORCID 0009-0004-4283-000XUnclaimed ORCID profile · follow to get notified of new preprints

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1

Frequent Co-Authors

Andrea J. TenchiD· 1 shared Anne‐Claude GingrasiD· 1 shared C. Jane McGladeiD· 1 shared Christopher FladdiD· 1 shared Claire Emilie MartiniD· 1 shared Craig D. SimpsoniD· 1 shared Danny T HuangiD· 1 shared Diane Ly· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperBiochemistry

Andrea J. TenchORCID

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1 paper

Recent·Most cited

BiochemistrybioRxivPreprintMar 18, 2026

Targeting CBL ubiquitin ligase activation to downregulate tyrosine kinase signalling

Andrea J. Tench, Claire Emilie Martin, Craig D. Simpson…·C. Jane McGlade

This study demonstrates that activating CBL ubiquitin ligase via engineered mutants or small molecules can downregulate tyrosine kinase signaling by enhancing substrate ubiquitination and reducing downstream signaling.

1 citation

experimental assay

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