Author

Diane Ly

Hospital for Sick ChildrenPrimary ORCID profile (0000-0002-8454-1810 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Diane LyiD2 papers

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Biochemistry· 1

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Approach:experimental assay· 1

Frequent Co-Authors

Andrea J. TenchiD· 1 shared Anne‐Claude GingrasiD· 1 shared C. Jane McGladeiD· 1 shared Christopher FladdiD· 1 shared Claire Emilie MartiniD· 1 shared Craig D. SimpsoniD· 1 shared Danny T HuangiD· 1 shared Leanne E. Wybenga-GrootiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Andrea J. TenchORCID

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1 paper

Recent·Most cited

Targeting CBL ubiquitin ligase activation to downregulate tyrosine kinase signalling

Andrea J. Tench, Claire Emilie Martin, Craig D. Simpson, Leanne E. Wybenga-Groot, Diane Ly, Christopher Fladd, Melissa Elgie, Syed Feroj Ahmed, Roger Belizaire, Danny T Huang, Anne‐Claude Gingras, C. Jane McGlade

This study demonstrates that activating CBL ubiquitin ligase via engineered mutants or small molecules can downregulate tyrosine kinase signaling by enhancing substrate ubiquitination and reducing downstream signaling.

bioRxiv · Mar 18, 2026 · PreprintBiochemistry