Andrea J. Tench

This study demonstrates that activating CBL ubiquitin ligase via engineered mutants or small molecules can downregulate tyrosine kinase signaling by enhancing substrate ubiquitination and reducing downstream signaling.

This study identifies how SLAP2 binding to CBL disrupts its autoinhibition, revealing a mechanism for activating CBL's ubiquitin ligase function.

The paper identifies ELT-3 as a GATA transcription factor that regulates cuticle collagen expression in C. elegans in response to environmental stimuli.