Melissa A. Yao

Evolution of oncogene amplification across 86,000 cancer cell genomes

The paper analyzes the evolutionary trajectories of high-level copy-number amplifications in cancer cell genomes to distinguish between extrachromosomal and intrachromosomal amplification mechanisms.

Dynamic optimization of extrachromosomal DNA copy number drives tumour evolution

This study shows ecDNA copy number plasticity drives tumour evolution by generating functional heterogeneity and promoting drug resistance.

miRISC inhibition causes mitotic defects and synergizes with genotoxic agents in cancers

The paper shows that inhibiting the HMWR complex causes mitotic defects and enhances cancer cell vulnerability when combined with genotoxic agents.

Ductal pancreatic cancer interception by FGFR2 abrogation

This study identifies FGFR2 as a key driver in early pancreatic tumorigenesis, showing that its inhibition can delay tumor formation and extend survival in mouse models.