Author

Lu M. Yang

Washington University in St. LouisORCID 0000-0001-7965-2674Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:differential expression· 4 Research Focus:clustering· 3 Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

David M. OrnitziD· 3 shared Aditi GnanasekariD· 1 shared Andrea VenturaiD· 1 shared Avi Ma’ayaniD· 1 shared Benjamin WerneriD· 1 shared Devika SrivastavaiD· 1 shared Ellis J. CurtisiD· 1 shared Howard Y. ChangiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersDevelopmental Biology

David M. OrnitzORCID

Mutual co-authors in cluster

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5 papers

Recent·Most cited

Cancer BiologybioRxivPreprintMar 23, 2026

Dynamic optimization of extrachromosomal DNA copy number drives tumour evolution

Aditi Gnanasekar, Shu Zhang, Ellis J. Curtis…·Paul S. Mischel

This study shows ecDNA copy number plasticity drives tumour evolution by generating functional heterogeneity and promoting drug resistance.

DOI 10.64898/2026.03.20.713026

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Cancer BiologyJournal of Biological ChemistryPeer-reviewedDec 20, 2025

Mitotic chromatin compaction tethers extrachromosomal DNA to chromosomes and prevents their mis-segregation into micronuclei

DOI 10.1016/j.jbc.2025.111081

humanDNA methylation

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Developmental BiologyDevelopmental DynamicsPeer-reviewedJun 3, 2020

Analysis of FGF20-regulated genes in organ of Corti progenitors by translating ribosome affinity purification

Lu M. Yang, Lisa Stout, Michael I. Rauchman, David M. Ornitz

The paper uses TRAPseq to identify FGF20-regulated genes in mouse organ of Corti progenitors, finding genes involved in hair cell differentiation and hearing loss.

9 citations

mousebulk RNA-seq

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Developmental BiologyPLoS GeneticsPeer-reviewedJul 5, 2019

Sox2 and FGF20 interact to regulate organ of Corti hair cell and supporting cell development in a spatially-graded manner

Lu M. Yang, Kathryn S.E. Cheah, Sung‐Ho Huh, David M. Ornitz

This paper investigates the interaction between Sox2 and Fgf20 in regulating organ of Corti development, showing their spatially-graded roles in specification and differentiation.

24 citations

mouseexperimental assay

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Developmental BiologyDevelopmental CellPeer-reviewedDec 27, 2018

Fate Before Function: Specification of the Hair Follicle Niche Occurs Prior to its Formation and Is Progenitor Dependent

Ka‐Wai Mok, Nivedita Saxena, Nicholas Heitman…·Michael Rendl

The paper shows that hair follicle niche precursors are specified before niche formation and requires FGF20 from progenitors.

117 citationstop 1%

mousebulk RNA-seq

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