Flavio H. Fenton

Real-Time GPU-Accelerated Digital Heart Twin: Integrating Bidirectional Interactions Between Living Optogenetic Monolayers and Computational Simulations

This paper develops a real-time digital heart twin system that integrates optogenetic cardiac monolayers with GPU-accelerated simulations to study reentrant arrhythmias.

Disturbed repolarisation-relaxation coupling during acute ischaemia permits systolic mechano-arrhythmogenesis.

This study shows that disturbed repolarisation-relaxation coupling during acute ischaemia increases systolic mechano-arrhythmogenesis, which can be mitigated by restoring coupling or targeting calcium, TRPA1, or ROS.

Mechanism of Arrhythmogenesis Driven by Early After Depolarizations in Cardiac Tissue

This study develops a computational model of early after depolarizations (EADs) in cardiac tissue, showing that EADs can emerge through a discontinuous bifurcation leading to arrhythmogenic alternans without ectopic beats.