Oleic acid triggers hippocampal neurogenesis by binding to TLX/NR2E1
Prasanna Kandel, Fatih Semerci, Aleksandar Bajić, Dodge L. Baluya, Lihua Ma, Kevin C. Chen, Austin C. Cao, Tipwarin Phongmekhin, Nick Matinyan, William Tin-Shing Choi, Alba Jiménez‐Panizo, Srinivas Chamakuri, Idris O. Raji, Lyra Chang, Pablo Fuentes‐Prior, , Mirjana Maletić‐Savatić
This study identifies oleic acid as a ligand for TLX/NR2E1 that promotes hippocampal neurogenesis by converting TLX from a repressor to an activator of cell cycle and neurogenesis genes.
bioRxiv · Oct 28, 2020 · PreprintNeuroscience