Author
Pfizer (United Kingdom)
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
4 papers
Recent·Most cited
Thomas O’Brien, Karolina Salciute, Shaylee R. Kieffer, Nehaa K. P. Ponraj, Madeleine Richer, Paulina Marzec, Caroline Benn, Darren G. Monckton, Vincent Dion, Robert S. Lahue
The paper introduces a new assay called TRX to monitor CAG*CTG triplet repeat expansions more rapidly and sensitively than existing methods.
bioRxiv · Dec 18, 2024 · PreprintGenetics
Sarah G. Aldous, Edward J. Smith, Christian Landles, Georgina F Osborne, María Cañibano-Pico, Iulia M Nita, Jemima M Phillips, Yongwei Zhang, Bo Jin, Marissa B. Hirst, Caroline Benn, Brian C Bond, Winfried Edelmann, Jonathan R. Greene, Gillian P. Bates
This study shows that reducing MSH3 in Huntington's disease mouse models prevents somatic CAG repeat expansion but does not accelerate disease onset, suggesting somatic expansion may not be required for pathogenesis.
Brain · Feb 21, 2024Peer-reviewedNeuroscience
Prasanna Kandel, Fatih Semerci, Aleksandar Bajić, Dodge L. Baluya, Lihua Ma, Kevin C. Chen, Austin C. Cao, Tipwarin Phongmekhin, Nick Matinyan, William Tin-Shing Choi, Alba Jiménez‐Panizo, Srinivas Chamakuri, Idris O. Raji, Lyra Chang, Pablo Fuentes‐Prior, , Mirjana Maletić‐Savatić
This study identifies oleic acid as a ligand for TLX/NR2E1 that promotes hippocampal neurogenesis by converting TLX from a repressor to an activator of cell cycle and neurogenesis genes.
bioRxiv · Oct 28, 2020 · PreprintNeuroscience
Jeremy Schwartzentruber, Stefanie Foskolou, Helena Kilpinen, Julia Rodrigues, Kaur Alasoo, Andrew J. Knights, Minal J Patel, Ângela Gonçalves, Rita Ferreira, Caroline Benn, Anna L. Wilbrey, Magda Bictash, Emma Impey, Lishuang Cao, Sergio Laínez, , Daniel J. Gaffney
The paper maps regulatory variants in iPSC-derived sensory neurons, identifying genetic influences on gene expression, chromatin accessibility, and RNA splicing, with overlaps to disease associations.
Nature Genetics · Dec 10, 2017Peer-reviewedGenomics