Male mice heterozygous for Protamine-1 and Protamine-2 are infertile displaying sperm damage and retention of Protamine-2 precursors, transition proteins and histones.
Gina Esther Merges, Chistoph Wiesejahn, Mar Domingo-Lopez, Simon Schneider, Andjela Kovacevic, Lena Arévalo, Hubert Schorle
The paper investigates the fertility of male mice with one allele loss of Prm1 and Prm2, finding infertility due to sperm damage and protamine precursor retention.
Andrology · Aug 20, 2026Peer-reviewedDevelopmental Biology