Andjela Kovacevic

XPO1 Inhibition by Selinexor Induces Nuclear p53 and p21 Accumulation, Cell-Cycle Arrest and Apoptosis in Testicular Germ Cell Tumors

This study shows selinexor, an XPO1 inhibitor, reduces viability and induces cell-cycle arrest and apoptosis in testicular germ cell tumors by increasing nuclear p53 and p21.

Male mice heterozygous for Protamine-1 and Protamine-2 are infertile displaying sperm damage and retention of Protamine-2 precursors, transition proteins and histones.

The paper investigates the fertility of male mice with one allele loss of Prm1 and Prm2, finding infertility due to sperm damage and protamine precursor retention.

Loss of perinuclear theca protein ACTRT2 causes subfertility and acrosome destabilization in mice

This study shows that ACTRT2 is essential for acrosome stability in mouse sperm, with its loss causing subfertility and structural defects during spermiogenesis.

Actin-related protein M1 (ARPM1) required for acrosome biogenesis and sperm function in mice

This study shows that ARPM1 is essential for acrosome biogenesis and sperm function in mice, with defects leading to subfertility and morphological abnormalities.

Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human

This study investigates the role of Cylicins in spermiogenesis and male fertility using gene-editing in mice and exome sequencing in humans, finding that Cylicin deficiency causes infertility and structural sperm abnormalities.

Actl7b-deficiency leads to mislocalization of LC8 type dynein light chains and disruption of murine spermatogenesis

This study shows that Actl7b deficiency in mice causes spermatogenic arrest and cytoskeletal defects in spermatids due to mislocalization of LC8 dynein light chains.