Simon Schneider

The paper investigates the fertility of male mice with one allele loss of Prm1 and Prm2, finding infertility due to sperm damage and protamine precursor retention.

This study shows that ACTRT2 is essential for acrosome stability in mouse sperm, with its loss causing subfertility and structural defects during spermiogenesis.

The paper investigates the relationship between protamine ratios and histone acetylation levels in sperm from mice and humans, finding reduced H4ac levels associated with altered protamine ratios.

This study investigates the role of Cylicins in spermiogenesis and male fertility using gene-editing in mice and exome sequencing in humans, finding that Cylicin deficiency causes infertility and structural sperm abnormalities.

This study shows that the cP2 domain is essential for proper sperm chromatin protamination and male fertility in mice.

This study shows that Prm1 deficiency in mice causes DNA damage, impaired PRM2 processing, and subfertility due to disrupted chromatin protamination.

This study shows TRIM71 is essential for germ cell development in mice and links TRIM71 variants to human male infertility.

This study investigates Prm2 deficiency in mice, showing it leads to oxidative stress and DNA damage during sperm maturation, affecting fertility.