Gina Esther Merges

This study shows selinexor, an XPO1 inhibitor, reduces viability and induces cell-cycle arrest and apoptosis in testicular germ cell tumors by increasing nuclear p53 and p21.

The paper investigates the fertility of male mice with one allele loss of Prm1 and Prm2, finding infertility due to sperm damage and protamine precursor retention.

This study shows that ACTRT2 is essential for acrosome stability in mouse sperm, with its loss causing subfertility and structural defects during spermiogenesis.

This study shows that ARPM1 is essential for acrosome biogenesis and sperm function in mice, with defects leading to subfertility and morphological abnormalities.

This study shows that protamine overexpression in somatic cells causes chromatin condensation and transcription suppression without altering DNA methylation.

The paper investigates the relationship between protamine ratios and histone acetylation levels in sperm from mice and humans, finding reduced H4ac levels associated with altered protamine ratios.

This study shows that Actl7b deficiency in mice causes spermatogenic arrest and cytoskeletal defects in spermatids due to mislocalization of LC8 dynein light chains.

This study shows that the cP2 domain is essential for proper sperm chromatin protamination and male fertility in mice.

This study shows that Prm1 deficiency in mice causes DNA damage, impaired PRM2 processing, and subfertility due to disrupted chromatin protamination.